Recent rapid increase of penicillin-resistant beta lactamase producing Neisseria gonorrhoeae in Korea makes it urgent to find suitable treatment regimens, especially because spectinomycin-resistant PPNG has been found in -Seoul.
Newer generation of cephalosporins are found to be effective in the treatment of gonorrhoea, especially against PPNG urethritis.
In this study, the effect of cefotaxime was compared with kanamycin in the treatment of uncomplicated male PPNG urethritis.
85 male patients with uncomplicated PPNG urethritis, which was detected by chromogenic cephalosporin method, at the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul were subjected to this study. 45 patients were treated with 1.0 gm cefotaxime Lm. plus 1.0 gm probenecid p.o., and 34 patients were followed. There were no treatment failures and 17(50.0%a) postgonococcal urethritis (PG). Other 40 patients were treated with 2.0 gm kanamycin Lm., and 36 patients were followed. There were 10(27.8%) treatment failures and 11(42.3%) PGU.
Cefotaxime gave significantly (p<0.001 ) superior result to kanamycin in the treatment of PPNG urethritis.
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